Abstract: The feasibility of laser welding to connect the vanadium alloy candidate material of ITER cladding was investigated. When the laser power is 2000 W, the welding speed is 10 mm/s, the spot diameter is 0.3mm, the vanadium alloy welded joint with good bonding condition was obtained, and the structure observation and mechanical property test were carried out. The results show that the vanadium alloy is well welded. The microstructure of the weld is mainly composed of a fine equiaxed crystal area（size about 10 μm） in the center of the weld and coarse columnar crystals near the fusion area. There is an obvious fusion line between the welding seam and the base metal. Because the carbon and oxygen contents in the welding seam area increase significantly, lath-like Ti（CO） precipitates appear. The hardness of the weld is about 750.6 HV,which is obviously hardened compared with the base metal. The strength of the welded joint is lower than that of the base material, the elongation is only 1/5 of the base material, and the fracture occurs in the weld zone. The increase of the content of impurity elements such as carbon and oxygen during the welding process and the generation of lath-like Ti（CO）precipitates reduce the room-temperature tensile properties of the vanadium alloy.