Abstract: In order to explore the optimal combination of low pressure casting process parameters for A356 aluminum alloy sleeve, numerical simulation of casting, response surface analysis method and genetic algorithm were used to optimize the upper die preheating temperature, the side die preheating temperature, the lower die preheating temperature and the casting temperature by taking the volume of shrinkage cavity and shrinkage porosity and the distance between secondary dendrite arms as the optimization objectives.The results show that the optimal process parameters are as follows: the upper die preheating temperature is 307℃, the side die preheating temperature is 330℃, the lower die preheating temperature is 394℃and the casting temperature is 701℃.The combination of optimized parameters can effectively improve the forming quality and mechanical properties of the castings.