Abstract: More and more attention has paid to the application of titanium aluminum alloy materials in key parts of rail vehicles. The Ti47.5Al2.5V1Cr titanium aluminum alloy and centrifugal casting shell formed by the mixing of Y₂O₃ and ZrO₂ were taken as the research object. Under different rotating speeds（300, 600, 900 r/min）, different pouring temperatures（1600,1650, 1700 ℃） and centrifugal radii（35, 55, 75 mm）, the microstructure morphology, phase composition, microstructure,element distribution and reaction layer thickness of the alloy interface reaction layer at different positions were studied. The microhardness changes of the alloy samples with the centrifugal radius, pouring temperature and rotation velocity were investigated. The results show that the thickness of the reaction layer of the castings formed by the alloy under different centrifugal casting conditions is different. The thickness of the reaction layer of the casting is mainly related to factors such as centrifugal speed, pouring temperature and centrifugal radius. The thickness of the casting reaction layer increases with the increase of rotation speed, pouring temperature and centrifugal radius.