Abstract: Inconel 718 nickel-based alloy formed by selective laser melting was subjected to homogenous aging（HSA）heat treatment, combined with microstructure analysis, tensile performance analysis and fracture morphology analysis, the hydrogen embrittlement of Inconel 718 alloy under in-situ hydrogen charging behavior was studied. The results show that the Inconel 718 nickel-based alloy undergoes HSA heat treatment, changing from the original cellular structure to slender columnar crystal. In the in-situ electrochemical hydrogen charging slow strain rate tensile test, the tensile strength after the HAS heat treatment increases from 1085 MPa in the as-SLM processed to 1459 MPa（increases by 22.5%）, and both the hydrogen-induced plasticity loss δ_L and the strength loss σ_Lare reduced. The strength and resistance to hydrogen embrittlement are significantly improved, and the plasticity is slightly reduced.