Abstract: Based on the real microstructure of TC11 titanium alloy, the numerical simulation of its micro mechanical properties was realized. The method and key steps of mechanical property simulation based on micro region structure were discussed. The micro region structure morphology was obtained by metallographic test and software processing. The material parameters of micro region phase composition were obtained by nano indentation test experiment and numerical calculation.And the finite element numerical simulation of micro region tensile loading process was realized by ABAQUS software. The results show that different phase structures of TC11 titanium alloy have different elastic modulus and yield strength. The elastic modulus and yield strength of the lamellar α +β phase are the smallest. The elastic modulus and yield strength of equiaxed α are the largest; And the elastic modulus and yield strength of the boundary between equiaxed α with lamellar structure are in the middle. At the same time, under the tensile loading boundary condition of 2000 N/m uniformly distributed load, the numerical yield strength of TC11 structure is 1020MPa and the numerical tensile strength is 1285 MPa. Under tensile loading, Equiaxed α phase deforms in the x direction first. And then under the coordination of lamella α+β phase deformation,the equiaxed α phase partial rotates and becomes deforming along the 45° direction. The stress concentration and fracture occur in equiaxed α phase and lamellar α+β phase boundary.