Abstract: In order to compare and study the effects of different surface modification and strengthening treatments on the wear resistance of TC6 titanium alloy, the ion nitriding, vacuum carburizing, electroless nickel plating and micro-arc oxidation strengthening technologies of titanium alloy were studied. The ring-block friction and wear tests were conducted for the friction pairs of TC6 titanium alloy actuating part in different strengthening states under simulated working conditions, and a suitable reinforcement method was selected to improve the service life of the actuating part. The results show that under the same load and time, the untreated titanium alloy test block experiences severe adhesive friction with the stainless steel test ring, with a friction coefficient of 0.82 and a wear rate of 4.96×10^-4mm³/（N·m）. Sliding friction occurs between test block and test ring after nitriding, hydrogen free carburizing and electroless nickel plating strengthening treatment, the friction coefficient is 0.32, 0.30, 0.34, respectively, and the wear rate is 5.39×10^-8mm³/（N·m）, 3.83×10^-7mm³/（N·m）, 3.48×10^-8mm³/（N·m）.After the friction and wear test of test block treated by micro-arc oxidation and the test ring, the film fails and adhesive friction occurs, the friction coefficient is about 0.56, and the wear rate is 1.43×10^-6mm³/（N·m）. The alloy has low surface hardness and poor wear resistance. The ion nitriding, hydrogen free carburizing and electroless nickel plating strengthening layers have good wear resistance, which are superior to the micro-arc oxidation strengthening layer.