Abstract: As the rolls in the roll column of the continuous casting machine cannot be avoided to produce errors in processing and installation, or the deformation and wear that occurs after a long period of operation, leading to its deviation from the original position and misalignment, which has a greater impact on the slab bulge deformation. Firstly, a slab solidification heat transfer model was established to get the growth of the slab shell during the cooling process. Secondly,based on the principle of high-temperature creep, a three-dimensional heat-force coupling model was established between the slab and the rollers to study the specific effect of roller misalignment on slab bulge deformation. In addition, the effect of roll spacing on slab bulge deformation was investigated under the consideration of roll misalignment. The results show that the roll misalignment has a greater impact on the slab bulge deformation, and the larger the amount of misalignment, the larger the slab bulge deformation. With the reduction of roller spacing, roller misalignment on the impact of slab bulge deformation continues to increase.