Abstract: GH4586 alloy is a new generation of nickel-based superalloy independently developed in China to replace GH4169 alloy, which is used as a key component of liquid rocket engines, and its fatigue characteristics have an important impact on service performance. The fatigue characteristics of GH4586 alloy at several typical temperatures（-196 ℃, room temperature, 400 ℃） were investigated. The original microstructure of GH4586 alloy was analyzed and characterized by metallographic microscope. The tensile and fatigue properties of GH4586 alloy at different temperatures were tested by electronic tensile testing machine and high-frequency fatigue testing machine. The fatigue fracture morphology at different temperatures was observed and analyzed by scanning electron microscopy. The results show that there are small and con tinuous carbide and TiN particles in the grain boundary. The average fatigue limits of -196 ℃, room temperature and 400 ℃ are 634 MPa, 440 MPa and 342.5 MPa, respectively. The linear relationship between cycle times and maximum fatigu e fracture stress at different temperatures is obtained by fitting higher stress levels. The fatigue fracture is cleavage fracture at -196 ℃,transgranular fracture at room temperature, and transgranular fracture and intergranular fracture at 400 ℃.