Abstract: Large titanium alloy ring parts for aviation have complex section and great size. Due to the different deformation and heat transfer conditions in different parts, the strain and temperature distribution in different regions of the ring cross-section will be uneven during rolling and heat treatment. Furthermore, the microstructure and mechanical properties of different regions of the ring are different, which greatly affects the overall mechanical properties of large titanium alloy rings. According to the strain distribution in different regions of the large ring, compression experiments with different deformation amounts were designed and different heat treatment processes were implemented to study the effects of different deformation amounts and annealing processes on the stru cture and mechanical properties of Ti-6Al-4V. The results show that the deformation has a significant effect on the size,content and morphology of α_pand β_tphases. With the increase of deformation amount, dynamic recrystallization occurs, the grain size of α_pand β_tphase decreases gradually and then increases, while the relative content of α phase increases gradually and then decreases. The tensile strength of the deformed Ti-6Al-4V alloy increases first and then decreases with the change of microstructure. After annealing, the size, content and morphology of α_pand β_tphases maintain the same change law as that of the deformed specimens, and the tensile strength and elongation of the annealed TC4 alloy increase first and then decrease, and the microstructure and properties show certain heritability.