Abstract: Composite honeycomb sandwich panels are widely used in the aerospace field, and their structural strength after damage repair directly affects the safety of equipment in service. Conducting intelligent design optimization of repaired structures is of significant importance for improving repaired structural strength, enhancing structural safety and reliability, and reducing repair costs. Based on the submodeling method and honeycomb equivalent analysis method, an integrated material-structure design method for repaired composite honeycomb sandwich panels was proposed. Firstly, an example of composite honeycomb sandwich panels under out-of-plane compression was performed based on the honeycomb equivalent analysis method. By comparing the ultimate loads of the detailed model and the equivalent model, the effectiveness of the equivalent model was verified. Then, a parametric submodel of a composite honeycomb sandwich panel was established and analyzed under typical loads. The effectiveness of the parametric submodel was verified by comparing the analysis results of the submodel and the global model. Finally, the repaired structure was optimized based on the genetic algorithm. The results show that the strength recovery ratio of the optimized repaired structures reaches 82.68%, which is 10.71% higher than that of the typical repaired structures, which validate the effectiveness of the proposed optimization method.