Abstract: On the Ti-6Al-4V substrate, Ti-6Al-4V/AlSi10Mg bimetallic materials were prepared using laser powder bed fusion (LPBF) and AlSi10Mg powder. The Ti-6Al-4V substrate and the LPBF-formed AlSi10Mg plate were butt assembled, and Ti-6Al-4V/AlSi10Mg bimetallic materials were prepared using MIG welding and 5083-Al welding wire and a comparative evaluation of interfacial microstructure and mechanical performance of the two bimetallic materials was carried out. The results show that the titanium/aluminum interface formed by the LPBF process exhibits liquid-liquid bonding characteristics, and due to the influence of local melting of the titanium substrate, the interface morphology and microstructure distribution are uneven.Whereas MIG welding results in a relatively planar solid-liquid interface. In contrast, the titanium/aluminum interface in MIG welding process is mainly solid-liquid bonded, with a relatively flat interface. The heat input differs between these two processes, leading to significant variations in interfacial grain size: the average grain size of the LPBF sample interface is 7.2 μm-9.5 μm, which is notably smaller than that of the MIG welding sample. The tensile strength and elongation of LPBF samples are 170 MPa and 2.56%, respectively, which are superior to those of MIG welding samples, which have a tensile strength of 160 MPa and an elongation of 0.94%. In addition, the microhardness of the aluminum alloy side of the LPBF sample is lower than that of the MIG welding sample.