Abstract: As a precipitation-strengthened wrought superalloy, GH4169 is mainly used in key components of aerospace, petrochemical, and nuclear industries, with a service temperature range of -250 ℃ to 650 ℃. Whatever the GH4169 superalloy components have been prepared by traditional processing technologies or advanced additive manufacturing processes, they need to undergo rational heat treatment before application to ensure excellent comprehensive properties and then meet the harsh service requirements. The microstructural evolution, precipitate characteristics, and their correlative effects on the mechanical properties of GH4169 superalloy treated by various heat treatment schemes were systematically summarized. The influences of heat treatment schemes on the alloy's hardness, room-temperature and high-temperature tensile properties, as well as stress rupture behavior were thoroughly elucidated, providing a foundational reference for the optimization of heat treatment process and the improvement of alloy performance.